The Deoxyribonucleases of Streptococcus pyogenes

The Deoxyribonucleases of Streptococcus Pyogens.

Streptococci of serological groups A and C are known to produce substantial amounts of extracellular deoxyribonuclease (l-4). Evidence that the nuclease activity is probably due to the presence of more than one enzyme was suggested by the finding of Bernheimer (5) that ribonucleic acid from a variety of sources could inhibit to varying degrees the DNase activity of group A streptococci but did ...

Streptococcus pyogenes ( Group A Streptococcus )

Group A streptococcus (GAS) is synonymous with Streptococcus pyogenes, the only species within this group of β-hemolytic streptococci. GAS is one of the leading pathogenic bacteria that infects children and adolescents, and is associated with a wide spectrum of infections and disease states. Worldwide, there are estimated to be >600 million cases of GAS pharyngitis (“strep throat”) and >100 mil...

Studies on Streptococcus Pyogenes

Electron microscopic observations of Streptococcus pyogenes (strain S43, type 6) treated with trypsin and cetyltrimethylammonium bromide (Cetab) are presented. The concentration of trypsin necessary to remove the M protein antigen was shown to bring about a partial digestion of the cells. The cell protoplasm and protoplasmic membrane were affected. No microscopic changes appeared in the cell wa...

Streptococcus pyogenes adcA

The Serum Opacity Reaction of Streptococcus Pyogenes

Investigation into the antigenicity of streptococcal lipoproteinase has revealed the existence of multiple, immunologically distinct enzymes. Each lipoproteinase identified was found to be strain specific in that it was found only in strains of a particular T-agglutination pattern. In some T patterns, all streptococci of that T pattern which were examined shared a common lipoproteinase antigen....